Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC VU0364572 (TFA) | 1240514-89-9 | 99.3% | 487.51 | 25 MG
VU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It demonstrates neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's Disease and is CNS penetrant.
- Orally active and selective allosteric agonist of the M1 muscarinic receptor.
- Neuroprotective potential for preventing memory impairments.
- Reduces neuropathology in Alzheimer's Disease.
- CNS penetrant.
Medchemexpress LLC Tcmcb07 (TFA) | 99.7% | 1230.46 (free base) | 5 MG
TCMCB07 (TFA) is a chemical product from MedChemExpress USA, identified for use as laboratory chemicals and for the manufacture of substances. It is supplied as a solid and is stable under recommended storage conditions.
- Designed for laboratory use and substance manufacturing
- Stable under recommended storage conditions
- Supplied as a solid
- Storage recommended at -80°C for 2 years or -20°C for 1 year (powder)
- Sealed storage, away from moisture and light
Medchemexpress LLC Ac-VDVAD-CHO (TFA) | 00-00-0 | 99.2% | 657.59 g·mol⁻¹ | C25H38F3N5O12 | 5 MG
Ac-VDVAD-CHO (TFA) is a peptide aldehyde inhibitor used in biochemical and cell-based research to block caspase-mediated proteolysis and investigate apoptosis pathways.
- Selective caspase-2 and caspase-3 inhibition (IC50 46 nM and 15 nM).
- TFA salt, supplied as a white to off-white solid.
- High purity (99.2%).
- Molecular weight 657.59 g·mol⁻¹; formula C25H38F3N5O12.
- Recommended storage: powder at -80°C (2 years) or -20°C (1 year).
- For research use only; not for human or clinical use.
Medchemexpress LLC Galnon (TFA) | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 g·mol⁻¹ | C42H47F3N4O8 | 25 MG
Galnon TFA is a selective, non-peptide agonist of the galanin receptors GAL1 and GAL2, with reported Ki values of 11.7 μM (GAL1) and 34.1 μM (GAL2). It is used in in vitro and in vivo research to study galanin receptor pharmacology and has demonstrated anticonvulsant and anxiolytic effects.
- Selective galanin receptor agonist with reported Ki values (GAL1 = 11.7 μM, GAL2 = 34.1 μM).
- Non-peptide small-molecule ligand suitable for receptor pharmacology studies.
- Demonstrated anticonvulsant and anxiolytic activity in preclinical studies.
- Supplied at high purity (98.88%) for research use.
- Available in small research-scale quantities, including 25 mg.
Medchemexpress LLC FTI-2153 (TFA) | 2820151-01-5 | 99.1% | 580.62 g/mol | C27H31F3N4O5S | 10MM 1ML
FTI-2153 TFA is the trifluoroacetic acid salt of a potent farnesyltransferase inhibitor supplied for research use. It is provided as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid amounts, with supporting datasheet, SDS, and COA for characterization and safe handling.
Medchemexpress LLC Tpp-CAQK TFA | 99.1% | 906.95 | 1 MG
Tpp-CAQK TFA is an engineered mitochondrial compound that can bind to mitochondria, enabling the construction of Mito-Tpp-CAQK TFA with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.
- Can bind to mitochondria
- Enables construction of Mito-Tpp-CAQK TFA
- Enhances macrophage phagocytosis of myelin debris
- Alleviates mitochondrial dysfunction
- Reduces proinflammatory profiles
- Facilitates tissue repair and functional recovery in mice after spinal cord injury
- For research use only
Medchemexpress LLC GpTx-1 TFA | 99.6% | 4073.82 (free base) | 1 MG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. It also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), demonstrating >20-fold and >950-fold selectivity, respectively. This product is for research use only.
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Exhibits >20-fold selectivity for NaV1.4 (IC50 = 0.301 μM).
- Exhibits >950-fold selectivity for NaV1.5 (IC50 = 4.20 μM).
- Isolated from the venom of the Chilean spider Grammostola porter.
Medchemexpress LLC Huwentoxin-IV TFA | 105856-78-4 | 99.04% | 4099.71 | 5 MG
Huwentoxin-IV TFA is a highly potent and selective blocker of neuronal voltage-gated sodium channels. It specifically inhibits NaV1.7 activity in human DRG neurons.
- Potent and selective sodium channel blocker
- Inhibits neuronal NaV1.7, NaV1.2, NaV1.3, and NaV1.4 channels
- IC50 of 2.9 nM for inhibiting NaV1.7-mediated currents
- Reduces NaV1.7 current amplitude by 50% at 0.5 nM
Medchemexpress LLC LARLLT (TFA) | 99.9% | 799.88 | 5 MG
LARLLT (TFA) is an EGFR-binding peptide with potential for research into EGFR overexpressing cancers, including lung, ovarian, and colorectal cancer.
- EGFR-binding peptide
- Potential for research of EGFR overexpressing cancers
- Targets EGFR
- Involves JAK/STAT signaling and protein tyrosine kinase/RTK pathways
- Sequence: Leu-Ala-Arg-Leu-Leu-Thr
- Molecular weight of 799.88
- Purity of 99.9% (HPLC)
- Soluble in DMSO: 50 mg/mL
- Appears as a white to off-white solid
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture)
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 5 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4) and exhibits antiviral activity. This product is for research use only and has not been fully validated for medical applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- For research use only
Medchemexpress LLC MPSD control peptide (TFA) | 99.8% | 3080.76 (free base) | 1 MG
MPSD TFA (MARCKS-ED TFA) is the TFA salt form of MPSD, a 25-amino acid peptide derived from the myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe capable of sensing membrane curvature and recognizing phosphatidylserine, making it useful for studying membrane shape and lipid composition.
- Derived from MARCKS effector domain sequence
- Senses membrane curvature
- Recognizes phosphatidylserine
- Useful for studying membrane shape and lipid composition
- Appears as a white to off-white solid
- High purity (99.8%)
- Molecular weight: 3080.76 (free base)