Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Cppi9 Tfa | 99.9% | 1553.37 | 5 MG
CPP9 TFA is a small, amphipathic, cyclic cell-penetrating peptide (CPP) that binds directly to plasma membrane phospholipids and enters mammalian cells via endocytosis. Its efficient release from the endosome after cellular entry makes it suitable for intracellular delivery of therapeutic agents and chemical probes.
- Efficient release from endosome after cellular entry
- Suitable for intracellular delivery of therapeutic agents
- Suitable for intracellular delivery of chemical probes
- For research use only
Medchemexpress LLC Astax-35r TFA | 99.1% | 2392.86 | 5 MG
aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. It competitively inhibits the binding of β-catenin to TCF4 and selectively induces growth inhibition of Wnt-dependent cancer cells.
- Antagonizes nuclear form of β-catenin.
- Inhibits Wnt signaling.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition of Wnt-dependent cancer cells.
TARGETMOL CHEMICALS INC MM-102 TFA 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor with an IC50 of 2.4 nM. This compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5), inhibiting MLL1 H3K4 histone methyltransferase (HMT) activity and down-regulating H3K4me3, which facilitates the epigenetic reprogramming of porcine somatic cell nuclear transfer embryos. Purity 99.3%
![Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate | 1336913-03-1 | 99.9% | 404.38 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438811-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate | 1336913-03-1 | 99.9% | 404.38 | 25 MG
PSEM 89S TFA is a selective and brain penetrant agonist for ion channels, orthogonally selective for Q79G and L141F. It is intended for research use only.
- Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance.
- Reversibly silences transfected neurons by reducing cellular input resistance.
- Reduces photostimulation-evoked feeding in mice with PSAML141F,Y115F-glycine receptor.
- Demonstrates good brain penetrance in mice after intraperitoneal administration.
- Suppresses fos in ChR2-expressing neurons in Agrp-cre mice.
- Shows rapid rise in serum and brain, cleared within 1 hour in C57BL/6 mice.
Medchemexpress LLC DPC-AJ1951 (TFA) | 99.4% | 1666.99 (free base) | 1 MG
DPC-AJ1951 TFA is a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption. In vitro, it induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR.
- Acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo assays of bone resorption
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR
- 14 amino acid peptide
Medchemexpress LLC Stressin I TFA | 98.63% | 4472.20 (free base) | 1 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent and selective agonist for the CRF1 receptor, intended for research use only. It has been shown to increase adrenocorticotropic hormone (ACTH) levels in rats.
- Potent CRF1 receptor selective agonist
- Ki of 1.7 nM
- Increases adrenocorticotropic hormone (ACTH) levels in rats
Medchemexpress LLC L-Serine, L-alanyl-L-prolyl-L-prolyl-L-histidyl-L-alanyl-L-leucyl- (TFA) | 99.87% | 805.80 | 25 MG
RS 09 TFA is an LPS peptide mimic and a TLR4 agonist. It binds to TLR-4, activating NF-κB, and functions as an adjuvant in vivo to enhance the antigen-specific immune response.
- Acts as an LPS peptide mimic and TLR4 agonist.
- Binds to TLR-4 and activates NF-κB.
- Enhances antigen-specific immune response in vivo.
- Stimulates TLR-4 and activates NF-κB in HEK-BLUETM-4 cells.
- Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells.
Medchemexpress LLC Siynfekl Tfa | 99.9% | 1013.14 | 1 MG
SIYNFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. It is an antigenic peptide that can stimulate specific T cells in experimental settings to study competitive interactions between T cells. SIYNFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR) and can be used for the detection of CD8+ T cells.
- Can stimulate specific T cells
- Used to study competitive interactions between T cells
- Exhibits low affinity for the OT-I T cell receptor (TCR)
- Can be used for the detection of CD8+ T cells
Medchemexpress LLC Stressin I TFA | 98.6% | 4472.20 | 5 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist with a Ki of 1.7 nM. It induces an increase in adrenocorticotropic hormone (ACTH) levels in rats. This product is for research use only and not sold to patients.
- Potent CRF1 receptor selective agonist
- Induces increase in adrenocorticotropic hormone (ACTH) levels
- White to off-white solid appearance
- For research use only
Medchemexpress LLC CMD178 TFA | 99.7% | 964.05 | 5 MG
CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Ra signaling. It also acts as an inhibitor of STAT5 and inhibits Treg cells development.
- Reduces expression of Foxp3 and STAT5 induced by IL-2/s IL-2Ra signaling
- Inhibits STAT5
- Inhibits Treg cells development
Medchemexpress LLC Ribupatide TFA | 2940971-65-1 | 99.8% | 4907.48 | 1 MG
Ribupatide TFA is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. It is orally active and can also be administered by injection, making it suitable for antidiabetic research.
- Dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist
- Can be studied in antidiabetic research
- Orally active
- Can also be administered by injection